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UniversidaddeCádiz
HEAT-Net Meeting 2024 Frontiers in Neurodegeneration: from bench to bedside

UniversidaddeCádiz

HEAT-Net Meeting 2024 Frontiers in Neurodegeneration: from bench to bedside
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Programme

Updated 4 de September de 2024
Posted 1 de February de 2024

HEAT-Net Meeting 2024

Frontiers in Neurodegeneration: from bench to bedside

 

Thursday September 5th

 

8:30-8:40: Welcome from the Organizing Committee, His Excellency Mr. Casimiro Mantell, President of the University of Cadiz, and Dr. Manuel Rosety, Dean of Medicine School

 

Session 1 – Biomarkers for prediction and diagnostics

8:40-9:00: Christina Lill: Prediction of neurodegenerative diseases in the longitudinal EPIC cohort using a multi-omics approach

9:00-9:20: Alberto Lleó: Update on blood biomarkers in Alzheimer’s disease

 

9:20-9:30 Discussion

 

9:30-10:15: Coffee

 

Session 2 – What is new in genetics?

10:15-10:35: Lars Bertram: The role of short tandem repeats in Alzheimer’s disease genetics (Online)

10:35-10:55: Mikko Hiltunen: Functional characterization of Alzheimer’s disease-associated genetic variants in NPH biopsy samples

 

10:55-11:05: Discussion

 

Session 3 – Cellular and animal models for neurodegeneration

11:05-11:20: Edward A. Stern: Development of a biophysical-based targeted dementia therapeutic system (Online)

11:20-11:35: Christine von Arnim: Cognitive impairment in an obesity mouse model

11:35-11:50: Monica Garcia-Alloza: Brain and retina in preclinical AD-type 2 diabetes models

 

11:50-12:05 Discussion

 

Session 4 – Novel potential therapeutic targets for neurodegeneration

12:05-12:25: Clévio Nóbrega: New players and targets in neurodegeneration: the case of spinocerebellar ataxias

12:25-12:45: Oksana Berezovska: Exploring a crosstalk between PS/g-secretase and glutamate transporter-1: relevance to Alzheimer’s disease

 

12:45-12:55: Discussion

 

12:55-15:00: Poster session and Lunch

 

Session 5 – Brief talks

15:00-16:00: Brief talks by junior investigators

– Elena Ppali: Endo-lysosomal dysfunction– related to progranulin-sortilin 1 pathway in neurodegeneration
– Bettina A. Zimmermann: Obese Aging: Investigation of the heart-brain axis in cognitively impaired MC4R mouse model
– Fátima Rubio-Pastor: Multiomic analysis upon genetic removal of CSPa/DNAJC5 in adulthood links altered lipid homeostasis to neurodegeneration
– Inés González-Reyes: Blood brain barrier alterations in a mixed murine model of Alzheimer’s disease and type two diabetes
– Rafael G. Costa: Understanding spinocerebellar ataxia type 2 disease progression through small extracellular vesicles
– Santiago Lopez Begines: Comparative Proteomic Analysis of Neuronal Ceroid Lipofuscinosis: Insights from Zebrafish and Mouse Models

 

 

Friday September 6th

 

Session 6 – Propagation and aggregation in neuroinflammation and neurodegeneration

8:30-8:50: Tiago Outeiro: Modeling and imaging protein aggregation in cells 

8:50-9:10: Pamela McLean: Cellular response to alpha-synuclein aggregation

9.10-9:30: Cintia Roodveldt: A new signaling kinase in microglia-mediated neuroinflammation and implications for neurodegenerative diseases

 

9:30-9:45: Discussion

 

9:45-10:15 Coffee

 

Session 7 – Synaptic pathology in neurodegeneration

10:15-10:35: Anna-Kaisa Haapasalo: Synaptic disturbances in frontotemporal dementia

10:35-10:55: Tara Spires-Jones: Synaptic tau – a tangled issue

10:55-11:15: Rafael Fernandez Chacon: Molecular pathophysiology of a synaptic co-chaperone in neurodegeneration

 

11:15-11:30: Discussion

 

Session 8 – Brief talks

11:30-12:30: Brief talks by junior investigators

– Kristjan Holt: Studying protein interactions in human synapses using array tomography
– Mónica García-Corrales: Cognitive profile and its relationship with brain atrophy in individuals with early-onset Alzheimer’s disease.
– Érika Sánchez-Aced: Unveiling the intraneuronal pattern of aβ immunoreactivity in different forms of Alzheimer’s disease
– Ricardo Pardillo-Díaz: Mobilizing neuroblasts from the subventricular zone to cortical injuries by activating neuregulin 1 release
– Siarhei Hladkou: Exploring dual-split AAV prime editing as a tool for gene therapy in Alzheimer’s disease
– Eugenia L Rodríguez Romero: Creatine supplementation prevents chronic colitis-induced decrease in hippocampal and subventricular zone proliferation and neurogenesis

 

12:30-15:00 Poster session and Lunch

 

Session 9 – Novel therapies

15:00-15:20: Martin Ingelsson: Development of immunotherapy for Parkinson’s disease

15:20-15:40: Teresa Gomez-Isla: New era and new challenges in the treatment of Alzheimer’s disease

 

15:40-16:00: Discussion

 

Session 10 – Keynote lecture

16:00-16:45: Brad Hyman: Testing assumptions about neurodegeneration in AD

 

16:45-17:00: Discussion

 

20:30: Closing dinner at “Bebo los vientos“

                 Paseo marítimo 12, Cádiz

       (Please note that confirmation is required)

 

 

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