#14

Title: GSK3β inhibition improves cognition and neuronal damage in a murine model of germinal matrix-intraventricular hemorrhage       

Authors: Isabel Atienza-Navarro (1,2); Angel del Marco (1,2); Antonio Segado-Arenas (2,3); Isabel Benavente-Fernandez (2,3,4); Carmen Gil (5); Ana Martinez (5,6); Simon Lubian-Lopez (2,3); Monica Garcia-Alloza (1,2)       

Affiliations: 1 Division of Physiology, School of Medicine, University of Cadiz, Cadiz, Spain; 2 Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz (INiBICA), Cadiz, Spain; 3 Division of Paediatrics, Section of Neonatology, Puerta del Mar University Hospital, Cadiz, Spain; 4 Area of Pediatrics, Department of Child and Mother Health and Radiology, Medical School, University of Cadiz, Cadiz, Spain; 5 Centro de Investigaciones Biologicas Margarita Salas, CSIC, Madrid, Spain; 6 Centro de Investigaciones Biomedicas en Red en Enfermedades Neurodegenerativas, CIBERNED, Madrid, Spain.      

 

 

#15    

Title: Studying protein interactions in human synapses using array tomography

Authors: Holt, K. (*1, 2), Taylor, L.W. (1, 2), McGeachan, R.I. (*1, 2), Simzer, E. (*1, 2), Colom-Cadena, M. (*1, 2), Sánchez-Aced, E. (*3), King, D. (*1, 2), Davies, C. (*1, 2), Hamby, M.E. (*4), Horrocks, M.H. (*5, 6), Lleo, A. (*3), Durrant, C.S. (*1, 2) and Spires-Jones, T.L. (*1, 2)

Affiliations: (*1) — Centre for Discovery Brain Sciences at the University of Edinburgh, Edinburgh, Scotland, United Kingdom; (*2) — UK Dementia Research Institute at the University of Edinburgh, Edinburgh, Scotland, United Kingdom; (*3) — Memory Unit, Department of Neurology, Institut de Recerca Sant Pau – Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; (*4) — Cognition Therapeutics, Inc, Pittsburgh, PA, USA; (*5) — Institute for Regeneration and Repair (IRR) at The University of Edinburgh, Edinburgh, Scotland, United Kingdom. (*6) — School of Chemistry, The University of Edinburgh, Edinburgh, United Kingdom. Research Funding: Cognition Therapeutics, Medical Research Council (MRC), UK Dementia Research Institute (UKDRI) and Race Against Dementia. 

 

 

#16    

Title: Cognitive profile and its relationship with brain atrophy in individuals with early-onset Alzheimer’s disease          

Authors: Mónica García-Corrales (1,2); Álvaro J. Cruz-Gómez (1,2); Luis Lobato (3); Elena Lozano-Soto (1,2); José Paz-Espósito (4); Guillermo Rubio-Esteban (3); Ana Gómez-Roldós (2,3); Javier J. González-Rosa (1,2).

Affiliations: 1. Department of Phycology, University of Cadiz, Spain; 2. Psychophysiology and Neuroimaging Group, Institute of Research and Biomedical Innovation of Cadiz (INiBICA), Spain; 3. Department of Neurology, Puerta del Mar University Hospital, Cadiz, Spain; 4. Department of Radiodiagnostic and Medical Imaging, Puerta del Mar University Hospital, Cadiz, Spain.  

 

 

#17    

Title: Unveiling the intraneuronal pattern of Aβ immunoreactivity in different forms of Alzheimer’s disease          

Authors: Érika Sánchez-Aced; Joaquim Aumatell; Itzel Prado-Gomez; Borja Moya-Llamas; Olivia Belbin; Juan Fortea; Sònia Sirisi* and Alberto Lleó*  

Affiliations: Memory Unit, Department of Neurology, Institut de Recerca Sant Pau – Hospital de Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.    

 

 

#18    

Title: Early stage, combating neurodegeneration induced by DNA damage through pharmacological testing in vitro model    

Authors: Rodrigo Paulino1,2,3, Ricardo Afonso-Reis1,2,3, Rafael G. Costa1,2,3 , Filipa Couto1,2,4, Clévio Nóbrega1,2,5,*               

Affiliations: (1) ABC-RI, Algarve Biomedical Center Research Institute, Universidade do Algarve, 8005-139 Faro, Portugal (2) FMCB, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, 8005-139 Faro, Portugal (3) FMCB, Faculdade de Medicina e Ciências Biomédicas, PhD program in Biomedical science, Universidade do Algarve, 8005-139 Faro, Portugal (4) FMCB, Faculdade de Medicina e Ciências Biomédicas, Master program in biomedical science, Universidade do Algarve, 8005-139 Faro, Portugal (5) Champalimaud Research Program, Champalimaud Center for the Unknown, 1400-038 Lisbon, Portugal (*) Author to whom correspondence should be addressed.  

 

 

#19

Title: Mobilizing neuroblasts from the subventricular zone to cortical injuries by activating neuregulin 1 release

Authors: Sonia Vázquez-de Górgolas (1); Patricia Pérez-García (1,2); Ricardo Gómez-Oliva (1,2); Samuel Domínguez-García (1,2); Ricardo Pardillo-Díaz (1,2); María Ortego-Domínguez (1,2); Nora Martínez-Gómez (3); Livia Carrascal (1,3); Rosario-Hernández-Galán (2,4); Pedro Núñez-Abades (1,3) and Carmen Castro (1,2)

Affiliations: 1 Biomedical Research and Innovation Institute of Cádiz (INiBICA). Cádiz, Spain; 2 Division of Physiology, University of Cádiz. Cádiz, Spain; 3 Department of Physiology. University of Seville. Seville, Spain; 4 Department of Organic Chemistry, University of Cádiz. Cádiz, Spain             

 

 

#20    

Title: Trmt2a suppression alleviates neurodegeneration in spinocerebellar ataxia type 3: Insights from a transgenic mouse model  

Authors: Tiago Moreira-Gomes (1,2, FCT fellowship: 2022.11008.BD) , David V.C. Brito (1), Ricardo Afonso-Reis (1,2), José Miguel Codêsso (1,2), Aaron Voigt (3,4), Clévio Nóbrega (1,2)         

Affiliations: 1 ABC-RI, Algarve Biomedical Center Research Institute, Universidade do Algarve, Faro, Portugal; 2 Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Faro, Portugal; 3 Department of Neurology, Medical Faculty, RWTH Aachen University; 4 JARA BRAIN Institute Molecular Neuroscience and Neuroimaging, Forschungszentrum Jülich GmbH and RWTH           

 

 

#22    

Title: Exploring dual-split AAV prime editing as a tool for gene therapy in Alzheimer’s disease

Authors: Siarhei Hladkou; Luisa Loreit; Sona Hakhverdyan; Vilmantas Giedraitis; Wojciech Michno; Martin Ingelsson

Affiliations: Uppsala University, Department of Public Health and Caring Sciences, Section of Geriatrics, Uppsala, Sweden           

 

 

#23

Title: The co-chaperone CSPα/DNAJC5 required to maintain Purkinje cell synaptic terminals

Authors: Carmen Paradela-Leal, Nozha Borjini, Elvira García-Guzmán, Pablo García-Junco Clemente and Rafael Fernández-Chacón

Affiliations: Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Depto. de Fisiología Médica y Biofísica & CIBERNED, Sevilla, Spain.

 

 

#24

Title: Neuronal damage induced by chronic colitis is ameliorated by creatine supplementation

Authors: Alejandro Ruiz-Calero1; Maria Ortego-Domínguez1,3; María D Vázquez-Carretero1; Gema Sotelo-Parrilla1; María L Calonge1; Ricardo Pardillo-Díaz1,2,3; Carmen Castro2,3; Pedro Nunez-Abades1,3; María J Peral1; Pablo García-Miranda1; Livia Carrascal1,3.

Affiliations: 1.Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain; 2.Departamento Fisiología, Facultad de Medicina, Universidad Cádiz, Spain; 3.Instituto de Investigación e Innovación Biomédica de Cádiz (INiBICA), Universidad Cádiz, Spain

 

 

#25

Title: Oxidative profile of a cohort of young versus aged individuals in the Algarve region

Authors: Daniela F. Santos 1,2, Sónia Simão 1,2,3 Nádia Silva 1,2, Ana Teresa Rajado 1,2, ALFA Score Consortium, Clévio Nóbrega 1,2,3,4, José Bragança 1,2,3,4,5 Pedro Castelo-Branco 1,2,3,4,5, Inês Araújo1,2,3,4,5

Affiliations: 1 Algarve Biomedical Center (ABC), University of Algarve, Gambelas Campus, Bld. 2, 8005-139 Faro, Portugal; 2 Algarve Biomedical Center Research Institute (ABC-RI), University of Algarve, Gambelas Campus, Bld. 2, 8005-139 Faro, Portugal; 3 Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Gambelas Campus, Bld. 2, 8005-139 Faro, Portugal; 4 ABC Collaborative Laboratory, Association for Integrated Aging and Rejuvenation Solutions (ABC CoLAB), 8100-735 Loulé, Portugal; 5 Champalimaud Research Program, Champalimaud Centre for the Unknown, Avenida Brasília, 1400-038 Lisbon, Portugal              

 

 

#26

Title: Creatine supplementation prevents chronic colitis-induced decrease in hippocampal and subventricular zone proliferation and neurogenesis   

Authors: Eugenia L Rodríguez-Romero; Alejandro Ruiz-Calero; María Saa-Pereira; Gema Sotelo-Parrilla; María L Calonge; María D Vázquez-Carretero; Pablo García-Miranda; María J Peral

Affiliations: Departamento de Fisiología, Facultad de Farmacia, Universidad de Sevilla, 41012 Sevilla, Spain.

 

 

#28

Title: Sex-based differences in neurogenesis and cognitive performance in a murine model of aging: a SAMP8 mouse study

Authors: Andrea Chamorro-Francisco(1,2), Ricardo Gómez-Oliva(1,2), Isabel Atienza-Navarro(1,2,), Sonia Vázquez-de Górgolas(2), Pedro Núñez-Abades(1,3) and Carmen Castro(1,2)

Affiliations: 1 Division of Physiology, University of Cádiz. Cádiz, Spain; 2 Biomedical Research and Innovation Institute of Cádiz (INiBICA). Cádiz, Spain; 3 Department of Physiology. University of Seville. Seville, Spain.