#01    

Title: Endo-lysosomal dysfunction– related to progranulin-sortilin 1 pathway in neurodegeneration           

Authors: Elena Ppali (1); Ville Leinonen (2); Eino Solje (3,6); Anna Mäki-Petäjä-Leinonen (4); Mikko Hiltunen (5); Annakaisa Haapasalo (1)

Affiliations: 1. A.I. Virtanen Institute for Molecular Sciences, UEF , Kuopio, Finland; 2 .Institute of Clinical Medicine – Neurosurgery and Neuro Center, Neurosurgery, Kuopio University Hospital, Finland; 3 .Institute of Clinical Medicine – Neurology, UEF and Neuro Center, Neurology, Kuopio University Hospital, Finland; 4 .UEF Law School, UEF, Joensu, Finland; 5. Institute of Biomedicine, UEF, Kuopio, Finland; 6. Neuro Center – Neurology, Kuopio University Hospital, Kuopio, Finland            

 

 

#02    

Title: Cognitive decline: a consequence of obese-ageing.             

Authors: Mansi Rajput1; Ihtzaz A. Malik1; Aditi Methi2; Jonathan A. C. Silva2; Jörg Wilting3; Andre Fischer2; Christine von Arnim1.        

Affiliations: 1. Department of Geriatrics, Universitätsmedizin Göttingen, Göttingen, Germany; 2. German Center for Neurodegenerative Diseases (DZNE), Göttingen, Germany; 3. Institute of Anatomy and Cell Biology, Universitätsmedizin Göttingen, Göttingen, Germany

 

 

#03    

Title: Obese aging: investigation of the heart-brain axis in cognitively impaired MC4R mouse model     

Authors: Bettina A. Zimmermann; Sabriela Tulani; Mansi Rajput; Jörg Wilting; Ihtzaz A. Malik; Christine von Arnim           

Affiliations: Department of Geriatrics, University Medical Center Göttingen, Göttingen, Germany 

 

 

#04

Title: Streptozotocin-induced type 1 diabetes modifies tau phosphorylation patterns and exacerbates cognitive impairment in the APP/PS1 mouse model of Alzheimer’s disease

Authors: Míriam Corraliza-Gómez* (1,2); María Vargas-Soria* (1,2); Carmen Infante-Garcia (1), Alan W. Stitt (3); Rafael Simó (4,5); Monica Garcia-Alloza (1,2)

Affiliations: 1. Division of Physiology. School of Medicine. Universidad de Cadiz. Cadiz, Spain; 2. Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz (INIBICA). Cadiz, Spain; 3. Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, Northern Ireland, UK; 4. Diabetes and Metabolism Research Unit. Vall d’Hebron Research Institute. Universitat Autònoma de Barcelona, Barcelona, Spain; 5. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain

 

 

#05

Title: Multiomic analysis upon genetic removal of CSPa/DNAJC5 in adulthood links altered lipid homeostasis to neurodegeneration  

Authors: Fátima Rubio-Pastor1; Alison Barbara Ross2; Ángel Márquez-Galera3; Santiago López-Begines1; Taekyung D. Yun4; Estela Area-Gómez4; Aysha María Bhojwani-Cabrera3; José P. López-Atalaya3; Marko Jovanovic2; Eugenio Fornasiero5; Rafael Fernández-Chacón1.

Affiliations: 1. Instituto de Biomedicina de Sevilla (IBiS, Hosp. Univ. Virgen del Rocío/CSIC/Universidad de Sevilla), Depto. de Fisiología Médica y Biofísica and CIBERNED ISCIII, 41013 Sevilla, Spain; 2. Department of Biological Sciences, Columbia University, New York, New York, USA; 3. Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas – Universidad Miguel Hernández, Sant Joan d’Alacant, 03550 Alacant, Spain; 4. Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA, and Department of Biomedicine, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Madrid, Spain; 5. Department of Neuro- and Sensory Physiology, University Medical Center Göttingen, 37073 Göttingen, Germany and Department of Life Sciences, University of Trieste, Trieste, Italy       

 

 

#06    

Title: Blood brain barrier alterations in a mixed murine model of alzheimer’s disease and type two diabetes             

Authors: Inés González-Reyes 1, 2; Ángel Del Marco 1, 2; Karis Little 3; Maria Llorian-Salvador 4; Alan W Sitt 3; Rafael Simó 4, 5; Mónica García-Alloza 1, 2

Affiliations: 1. Division of Physiology. School of Medicine, University of Cadiz, Cadiz, Spain; 2. Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz (INIBICA), Cadiz, Spain; 3. Centre for Experimental Medicine, Queen’s University Belfast, Northern Ireland, UK; 4. Diabetes and Metabolism Research Unit, Vall d’Hedron Research Institute (VHIR), Barcelona, Spain; 5. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEMI, Instituto de Salud Carlos III (ICSIII), Madrid, Spain.

 

 

#07

Title: Prediabetes and type 2 diabetes alter tau phosphorylation, neuroinflammation and cognition in murine models of Alzheimer’s disease            

Authors: Maria Vargas-Soria* (1,2); Miriam Corraliza-Gomez* (1,2); Carmen Infante-Garcia (1); Alan W. Stitt (3); Rafael Simó (4,5); Monica Garcia-Alloza (1,2)

Affiliations: 1. Division of Physiology. School of Medicine. Universidad de Cadiz. Cadiz, Spain; 2. Instituto de Investigacion e Innovacion en Ciencias Biomedicas de la Provincia de Cadiz (INIBICA). Cadiz, Spain; 3. Wellcome-Wolfson Institute for Experimental Medicine, Queen’s University Belfast, Belfast, Northern Ireland, UK; 4. Diabetes and Metabolism Research Unit. Vall d’Hebron Research Institute. Universitat Autònoma de Barcelona, Barcelona, Spain; 5. Centro de Investigación Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

 

 

#08

Title: Understanding spinocerebellar ataxia type 2 disease progression through small extracellular vesicles         

Authors: Rafael G. Costa 1,2,3 , Carlos A. Matos 1 , Tiago Outeiro 3 , Clévio Nóbrega 1      

Affiliations: 1 Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Faro, Portugal, 2 Doctoral program in Biomedical Sciences, Universidade do Algarve, Faro, Portugal, 3 Department of Experimental Neurodegeneration, Göttingen, Germany 

 

 

#09

Title: Activity regulated inhibitor of death gene expression: the case of spinocerebellar ataxia type 2 and type 3

Authors: Inês T. Afonso1,2,3,4, David V. C. Brito2, Hilmar Bading4, Clévio Nóbrega1,2

Affiliations: 1 Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Faro, Portugal; 2 Algarve Biomedical Center – Research Institute, Faro, Portugal, 3PhD Program in Biomedical Sciences, Faculdade de Medicina e Ciências Biomédicas, Universidade do Algarve, Faro, Portugal; 4Interdisciplinar Center for Neuroscience, Heidelberg, Germany.

 

 

#10    

Title: Comparative Proteomic Analysis of Neuronal Ceroid Lipofuscinosis: Insights from Zebrafish and Mouse Models        

Authors: Santiago López-Begines1,2, Úrsula Heins-Marroquín1,3, Rafael Fernández-Chacón2, Carole Linster1.    

Affiliations: 1.Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Belvaux, Luxembourg, 2. Instituto de Biomedicina de Sevilla (IBiS, Hosp. Univ. Virgen del Rocío/CSIC/Universidad de Sevilla) and CIBERNED ISCIII, Depto. Fisiología Médica y Biofísica, Sevilla, Spain; 3. Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.               

 

 

#11

Title: Developing a tool for imaging mitochondrial protein import in real time 

Authors: Mario López-Manzaneda1,2; Jaime de Juan-Sanz1 and Rafael Fernández-Chacón2

Affiliations: 1- Institut du Cerveau (ICM) Laboratoire Physiologie Moleculaire de la Bioenergetique Synaptique, Paris, France. 2- Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Dpto. de Fisiología Médica y Biofísica, Facultad de Medicina and CIBERNED ISCIII, Sevilla, Spain.

 

 

#12

Title: Proteomics analysis of lysosomes lacking the molecular co-chaperone CSPα/DNAJC5 reveals a connection with cholesterol homeostasis

Authors: Emanuela Tumini; Santiago López-Begines; Rafael Fernández-Chacón

Affiliations: Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Dpto. de Fisiología Médica y Biofísica, Facultad de Medicina and CIBERNED ISCIII, Sevilla, Spain.

 

 

#13    

Title: Study of the role of the co-chaperone CSPα/DNAJC5 in the maintenance of dopaminergic nigrostriatal axonal terminals

Authors: Innas Ouled Chaara; Carmen Paradela-Leal; Santiago López-Begines; Nozha Borjini; Rafael Fernández-Chacón.

Affiliations: Instituto de Biomedicina de Sevilla (IBiS, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla), Dpto. de Fisiología Médica y Biofísica, Facultad de Medicina and CIBERNED ISCIII, Sevilla, Spain.

 

#21     

Title: Exploring Ketotifen’s Impact on Age-Related Neuroinflammation

Authors: Lorenzo Barrella (1); Juan A. Flores (2); Victoria Vázquez-Román (3); Mª Dolores Maldonado (2); Marta San Millán-Huang (1); Pilar Ramírez-Ponce (1); Eva Alés (1).

Affiliations: (1) Departamento de Fisiología Médica y Biofísica, Facultad de Medicina, Universidad de Sevilla, Sevilla, España; (2) Departamento de Bioquímica Médica y Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, Sevilla, España; (3)Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, Sevilla, España.